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KMID : 0369820050350030143
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Jorunal of Korean Pharmaceutical Sciences
2005 Volume.35 No. 3 p.143 ~ p.150
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Preparation and Evaluation of Solid Lipid Nanoparticles(SLNs) containing 5-Fluorouracil and Its Derivative
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서혜선/Suh HS
최명신/한규원/박소민/김길수/Choi MS/Han KW/Park SM/Kim KS
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Abstract
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Solid lipid nanoparticles(SLNs) are particulate systems for parenteral drug administration and have good biocompatibility and stability. SLNs were prepared with lauric acid, as the lipid core. Tween 20 and tween 80 were used as surfactant. 5-fluorouracil and l-benzoyl-5-fluorouracil were used as model drugs. Drug-loaded SLNs were prepared by the hot homogenization technique in order to evaluate the physical stability, entrapment efficiency of drugs as well as release profile. The particle size of SLNs was 40~600 nm. By increasing speed, the mean particle size of SLNs was decreased. And entrapment efficiency in the case of using 1-Benzoyl-5-fluorouracil was higher than using 5-Fluorouracil. The higher surfactant concentration, the faster release rate at the range of 1.5~2.5%.
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KEYWORD
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SLNs, 5-fluorouracil, 1-benzoyl-5-fluorouracil
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